Site-selective reactions mediated by molecular containers

• Rui Wang and
• Yang Yu

Beilstein J. Org. Chem. 2022, 18, 309–324, doi:10.3762/bjoc.18.35

• ; microenvironment; molecular containers; noncovalent protective group; site-selectivity; Introduction To run reactions with discriminate control over product selectivity represents one of the huge challenges in organic synthetic chemistry [1], among which, site-selectivity is always crucial to a reaction when

• container as the noncovalent protective group, the Pitchumani and Srinivasan group also reported that the reduction of coumarin (18) by sodium borohydride could be site-selectively induced in the presence of β-cyclodextrin C (Figure 4c) [59]. The reduction site-selectively occurred at the carbonyl not the

• effect of the reaction to terminal site-selectivity compared to the reaction in the absence of cage J. Even though the induced terminal site-selectivity in this work was not significant, it set an early example of how the molecular container could be beautifully used as a noncovalent protective group for